Biochem/physiol Actions

Cell permeable: no

Reversible: no

Product does not compete with ATP.

Primary TargetMMP-1, MMP-8

General description

A tetrapeptidyl hydroxamic acid that inhibits interstitial and granulocyte collagenases (MMP-1 and MMP-8; IC₅₀ = 1 µM), granulocyte gelatinase (MMP-9; IC₅₀ = 30 µM), adn skin fibroblast stromelysin (MMP-3; IC₅₀ = 150 µM). Retains its activity even after prolonged incubation with PRONASE™ Protease (Cat. No. 53702) or human neutrophil elastase.

A tetrapeptidyl hydroxamic acid that inhibits MMP-1 and MMP-8 (IC₅₀ = 1.0 µM), MMP-9 (IC₅₀ = 30 µM) and MMP-3 (IC₅₀ = 150 µM). Retains its activity even after prolonged incubation with PRONASE™ Protease (Cat. Nos. 53702 or 537088) or human granulocyte elastase.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Hagemamn, T., et al. 2004. Carcinogenesis25, 1543.Odake, S., et al. 1994. Biochem. Biophys. Res. Commun. 199, 1442.

Packaging

10 mg in Plastic ampoule

Reconstitution

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Sequence

4-Abz-Gly-Pro-D-Leu-D-Ala-NH-OH [Abz = aminobenzoyl]

Warning

Toxicity: Standard Handling (A)